A young woman presenting a kikuchi-fujimoto’s disease associated with induced lupus
|Submitted||Original manuscript||16th Jul 2018|
|Submitted||Version 2||24th Sep 2018|
|Accepted||Editorial Acceptance||05th Nov 2018|
|Published||Online||23rd Nov 2018|
Introduction: Kikuchi-Fujimoto’s disease (KFD) or histiocytic necrotizing lymphadenitis is a benign and self-limited disease of unknown etiology mainly affecting young women. Although the association with systemic lupus erythematosus (SLE) is well described, no case of drug-induced lupus erythematosus (DILE) associated KFD has not been reported so far.
Case report: We herein report a 25-year old Caucasian woman, with no medical history and no medication except for oral estrogen-progestin contraception (levonorgestrel-ethinylestradiol), who presented with cervical lymphadenopathy, fever and arthralgia without weight loss, night sweats or skin involvement. An exhaustive infectious disease screening was negative and lymph node biopsy revealed histiocytic necrotizing lymphadenitis suggesting KFD. Autoimmune screening tests evidenced high titers of anti-histone antibodies suggesting DILE induced by estrogen-progestin medication. The patient received a short course of non-steroidal anti-inflammatory treatment for painful lymphadenitis and arthralgia. Oral levonorgestrel-ethinylestradiol contraceptive medication was stopped and KFD and DILE completely recovered with a long-term disappearance of anti-histone antibodies.
Conclusion: We report the first case of KFD associated-DILE following oral levonorgestrel-ethinylestradiol medication. Even though levonorgestrel-ethinylestradiol induced lupus is well known, the association with KFD has never been reported and the physiopathology remained unknown.
Keywords: Kikuchi-Fujimoto disease, Lupus, Levonorgestrel-ethinylestradiol
Kikuchi-Fujimoto’s disease (KFD) or histiocytic necrotizing lymphadenitis is a rare, benign and self-limited disease revealing itself by cervical lymphadenopathy and high-grade fever, mainly affecting young women. It was first described in 1972 by Kikuchi and Fujimoto. The diagnosis is made by lymph node histology: histiocytic necrotizing lymphadenitis which is characterized by patchy areas of necrosis, with eosinophilic materials and nuclear debris and the absence of neutrophils [1,2].
The etiology is still unknown butviral etiologysuch as Epstein Barr virus (EBV)  or Human Herpes virus 7 (HHV7)  have been proposed. This disease can be isolated or associated with systemic diseases, in particular with systemic lupus erythematosus (SLE), preceding, coexisting or following the diagnosis [5,6]. The main differential diagnosis are infectious diseases and lymphomas.
Drug-induced lupus erythematosus (DILE) is a variant of lupus erythematosus that resolves within days to months after withdrawal of the drug in a patient with no underlying immune system dysfunction. DILE can arise months to years after exposure to the drug. The most common drugs that cause DILE are hydralazine, procainamide, quinidine, isoniazid, diltiazem, and minocycline .
Although the association with systemic lupus erythematosus is well described [5,6], no case of drug-induced lupus erythematosus associated KFD has not been reported so far.
We report the case of a KFD preceding a DILE.
We herein report a 25-year old Caucasian woman, with no medical history and no medication except for oral estrogen-progestin contraception (levonorgestrel-ethinylestradiol called Minidril®), who presented with cervical lymphadenopathy, fever and arthralgia without weight loss, night sweats or skin involvement.Blood analysis revealed normal blood cells count (leukocytes 5200/mm3, hemoglobin 12.4g/dL, platelets 258 000/mm3) liver. Serum complement C3and C4 levels were 1.23g/L (Normal range 0.8-1.8g/L) and 0.16g/L (Normal range 0.15-0.45g/L), respectively. The C- reactive protein (CRP) level was 10mg/L (Normal range < 3mg/l).
An exhaustive infectious disease screening was negative in particular HIV, CMV, EBV, toxoplasmosis, HHV6, HHV7, HHV8, parvovirus B19, brucellosis serology. A whole-body scanner only showed the known cervical lymphadenopathy. The lymph node biopsy revealed histiocytic necrotizing lymphadenitis (figure 1), suggesting diagnosis of KFD. Autoimmune screening tests were realized: antinuclear, native-anti DNAs, and anti ENA antibodies were negative but anti-histone titer was borderline (26 UI/L). The patient revised 3 months later with persistence of cervical lymphadenopathy and arthralgia. A new autoimmune screening was realized and found positive native anti-DNA antibodies (88UI/L) and positive anti histone (>300UI/L) evoking strongly a drug-induced lupus erythematosus. The patient received a short course of non-steroidal anti-inflammatory treatment for painful lymphadenitis and arthralgia and her only long-term treatment, oral estrogen-progestin contraception, was stopped.
Cervical lymphadenopathy and arthralgia had completely disappeared 6 months later. Anti-DNA and anti-histone antibodies and CRP were also negative. KFD and DILE completely recovered after levonorgestrel-ethinylestradiol withdrawal with a long-term disappearance ofanti-DNAs and anti-histone antibodies.